SARS-CoV-2 has been shown to bind optimally to the human ACE2 receptors, which are expressed mostly in cells that line the circulatory system (arteries, veins and capillaries), as well as the lungs, kidneys and gastrointestinal tract.
The Spike Protein is exposed.
The Nucleocapsid protein is present in the viral membrane and is not exposed.
New protein expression vector which forms and secretes a chimeric soluble protein that delivers the viral antigen into mucosal tissues by self-activated endocytosis.
The characterization of viral protein domains enhances a specific anti SARS-CoV-2 mucosal immune activity based on a specific structural pattern of the SARS-CoV-2 S and N proteins, which is sufficient for the induction of an effective immune response.
The SARS-CoV-2 binds optimally to the human ACE2 receptors via the exposed Spike Protein.
Penetration to the human cell (via ACE2 receptor) throughout the Spike protein:
